The main content area, the Photoshop logo - what is that all about? Maybe you should actually put in some structured content (a text header and a paragraph of
http://lipsum.com) to enable us to see what it would look like with proper content.
The outer shadow glows are too dark, lighten them.
You need to have a different shade of background for the inner main content area box, rather than being transparent, as this will distinguish more of a focus on the main content area.
The navigation structure seems a bit random, usually you have the main links on the header, instead of the footer, this is something to consider for accessibility reasons. The buttons also look too techy/futuristic but I guess this is the general look of the layout.
There is also too much blue